Proef de zuiverheid van echte saffraan 
100% biologisch

Saffraan is niet alleen een heerlijke toevoeging aan uw gerechten, maar biedt ook tal van gezondheidsvoordelen. 

In de Perzische en de Chinese geneeskunde wordt saffraan al meer dan 4000 jaar als geneesmiddel ingezet tegen de meest uiteenlopende klachten op het gebied van bloed, spijsvertering, longen, vruchtbaarheid en psyche.

Mehrin saffraan kan ook worden ingezet:

  • Bij een depressie 
  • Bij een burn-out
  • Bij overspannenheid
  • Bij veel stress
  • Bij een laag libido
  • Bij chronische ontstekingen.
  • Bii slaapproblemen 
  • Bii Menopauze
  • Bii Astma  
  • Bij ADHD
  • Bij COVID-19 

 

Depressie (majeure depressie, postnatale depressie, depressie bij jongeren en ouderen) Stress en angst (acuut, chronisch) OCS (obsessieve-compulsieve stoornis) Premenstrueel syndroom (PMS) en premenstruele dysfore stoornis (PMDD) Menopauze (psychische klachten) Slaapproblemen Oogaandoeningen (zoals leeftijdsgerelateerde maculadegeneratie, glaucoom, diabetische retinopathie, retinitis pigmentosa) Hersenziekten (zoals ziekte van Alzheimer, de ziekte van Parkinson, multiple sclerose, ischemische beroerte) Seksuele dysfunctie (mannen, vrouwen), waaronder laag libido, impotentie Verminderde vruchtbaarheid (mannen) Afvallen, metabool syndroom Diabetes mellitus Allergisch astma Reumatoïde artritis Fibromyalgie ADHD COVID-19

Bronnenlijst:

Literatuur

1. Tóth B et al. The efficacy of saffron in the treatment of mild to moderate depression: a meta-analysis. Planta Med. 2019;85(1):24-31.
https://pubmed.ncbi.nlm.nih.gov/30036891/ 

 

2. Yang X et al. Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials. https://www.dovepress.com/comparative-efficacy-and-safety-of-crocus-sativus-l-for-treating-mild--peer-reviewed-fulltext-article-NDT Neuropsychiatr Dis Treat. 2018;14:1297-1305.

 

3. Bangratz M et al. A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depression. https://pmc.ncbi.nlm.nih.gov/articles/PMC6049049/ Neuropsychiatr Dis Treat. 2018;14:1821-1829.


4. Lopresti AL et al. Affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: a randomised, double-blind, placebo-controlled study. https://pubmed.ncbi.nlm.nih.gov/29510352/
J Affect Disord. 2018;232:349-357.

5. Lopresti AL et al. The effects of a saffron extract (affron®) on menopausal symptoms in women during perimenopause: a randomised, double-blind, placebo-controlled study.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408316/ J Menopausal Med. 2021;27(2):66-78.


6. Ahmadpanah M et al. Crocus Sativus L. (saffron) versus sertraline on symptoms of depression among older people with major depressive disorders-a double-blind, randomized intervention study. https://pubmed.ncbi.nlm.nih.gov/31669837/  Psychiatry Res. 2019;282:112613.

 

7. Kashani L et al. Comparison of saffron versus fluoxetine in treatment of mild to moderate postpartum depression: a double-blind, randomized clinical trial. https://www.ncbi.nlm.nih.gov/pubmed/27595298 Pharmacopsychiatry. 2017;50(2):64-68.

 

8. Soheilipur K et al. Comparing the effects of saffron, lippia, and saffron-lippia combination on anxiety among candidates for coronary angiography. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554287/ Avicenna J Phytomed. 2021;11(5):515-526.

9. Esalatmanesh S et al. Comparison of saffron and fluvoxamine in the treatment of mild to moderate obsessive-compulsive disorder: a double blind randomized clinical trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640576/ Iran J Psychiatry. 2017;12(3):154-162.

 

10. Konstantinos IA et al. Effects of saffron (Crocus sativus L.) on cognitive function. A systematic review of RCTs. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640576/ Neurol Sci. 2020;41:2747-54.

 

11. Bian Y et al. Neuroprotective potency of saffron against neuropsychiatric disease, neurodegenerative disease, and other brain disorders: from bench to bedside. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484083/ Front Pharmacol. 2020;11:579052.


12. Saeedi M et al. Association between chronic stress and Alzheimer's disease: therapeutic effects of saffron.https://www.sciencedirect.com/science/article/pii/S0753332220311872?via%3Dihub Biomed Pharmacother. 2021;133:110995.


13. Batarseh YS et al. Crocus sativus extract tightens the blood-brain barrier, reduces amyloid β load and related toxicity in 5XFAD mice. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559303/ ACS Chem Neurosci. 2017;8(8):1756-1766.


14. Azami S et al. Therapeutic potential of saffron (Crocus sativus L.) in ischemia stroke. https://www.hindawi.com/journals/ecam/2021/6643950/ Evid Based Complement Alternat Med. 2021;2021:6643950.

 

15. Heitmar R et al. Saffron (Crocus sativus L.) in ocular diseases: a narrative review of the existing evidence form clinical studies. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471055/ Nutrients 2019;11:649.

 

16. Fernández-Albarral JA et al. Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059587/ Neural Regen Res. 2020;15(8):1408-1416.

 

17. Lopresti A et al. An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study. https://pubmed.ncbi.nlm.nih.gov/34438361/ Sleep Med. 2021;86:7-18.


18. Lopresti AL et al. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849671/ 
J Clin Sleep Med. 2020;16(6):937-947.

 

19. Fatemeh Rajabi et al. Saffron for the management of premenstrual dysphoric disorder: a randomized controlled trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792881/ Adv Biomed Res. 2020;9:60.

 

20. Nemat Shahi M et al. The impact of saffron on symptoms of withdrawal syndrome in patients undergoing maintenance treatment for opioid addiction in Sabzevar parish in 2017. https://www.hindawi.com/journals/amed/2017/1079132/ Adv Med. 2017;2017: 1079132.

 

21. Khorasany AR et al. Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923465/ Iran J Basic Med Sci. 2016;19(5):455-69.

 

22. Tahvilian N et al. Effects of saffron supplementation on oxidative/antioxidant status and severity of disease in ulcerative colitis patients: A randomized, double-blind, placebo-controlled study. https://pubmed.ncbi.nlm.nih.gov/33015869/ 
Phytother Res. 2021;35(2):946-953.

 

23. Razavi BM et al. Saffron: a promising medicine in the treatment of metabolic syndrome.https://www.ncbi.nlm.nih.gov/pubmed/27861946  J Sci Food Agric. 2017;97(6):1679-85.

 

24. Moravej Aleali A et al. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double-blind clinical trial. https://pubmed.ncbi.nlm.nih.gov/30942510/ Phytother Res. 2019;33(6):1648-1657.

 

25. Mobasseri M et al. Effects of saffron supplementation on glycemia and inflammation in patients with type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical trial study. https://pubmed.ncbi.nlm.nih.gov/32408117/ Diabetes Metab Syndr. 2020;14(4):527-534.

 

26. Hatziagapiou K et al. The protective role of Crocus sativus L. (saffron) against ischemia-reperfusion injury, hyperlipidemia and atherosclerosis: nature opposing cardiovascular diseases. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300793/ Curr Cardiol Rev. 2018;14(4):272-289.

 

27. Setayesh L et al. The effect of saffron supplementation on blood pressure in adults: a systematic review and dose-response meta-analysis of randomized controlled trials. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398601/ 
Nutrients. 2021;13(8):2736.

 

28. Shakeri M et al. Toxicity of saffron extracts on cancer and normal cells: a review article. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573418/ Asian Pac J Cancer Prev. 2020;21(7):1867-1875.

 

29. Zeinali M et al. Immunoregulatory and anti-inflammatory properties of Crocus sativus (saffron) and its main active constituents: a review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535192/  Iran J Basic Med Sci. 2019;22(4):334-344.


30. Maleki-Saghooni N et al. A systematic review and meta-analysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987435/ Avicenna J Phytomed. 2018;8(3):198-209.


31. Ranjbar H et al. Effects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727438/ Avicenna J Phytomed. 2019;9(5):419-427.


32. Zilaee M et al. An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387530/ Respir Res. 2019;20(1):39.

33. Poursamimi J et al. Crocus sativus (saffron): an immunoregulatory factor in the autoimmune and non-autoimmune diseases. Iran J Allergy https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2586/1582 Asthma Immunol. 2020;19(S1):27-42.

34. Hamidi Z et al.The effect of saffron supplement on clinical outcomes and metabolic profiles in patients with active rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. https://pubmed.ncbi.nlm.nih.gov/32048365/ Phytother Res. 2020;34(7):1650-1658.

 

35. Baziar S et al. Crocus sativus L. versus methylphenidate in treatment of children with attention-deficit/hyperactivity disorder: a randomized, double-blind pilot study. https://pubmed.ncbi.nlm.nih.gov/30741567/ Psychopharmacol. 2019;29(3):205-212.

 

36. Husaini AM et al. Saffron: a potential drug-supplement for severe acute respiratory syndrome coronavirus (COVID) management.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118646/  Heliyon. 2021;7(5):e07068.


37. Kianmehr M et al. Possible therapeutic effects of Crocus sativus stigma and its petal flavonoid, kaempferol, on respiratory disorders. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746242/ Pharm Biol. 2020;58(1):1140-1149.

 

38. Nemat Shahi M et al. The impact of saffron on symptoms of withdrawal syndrome in patients undergoing maintenance treatment for opioid addiction in Sabzevar Parish in 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735591/ adv Med. 2017;2017:1079132.


39. Lambrianidou A et al. Recent advances on the anticancer properties of saffron (Crocus sativus L.) and its major constituents. https://www.mdpi.com/1420-3049/26/1/86/htm Molecules. 2020;26(1):86.

40. Bostan HB et al. Toxicology effects of saffron and its constituents: a review. Iran J Basic Med Sci. 2017;20(2):110-121. 41. Shakiba M et al. Saffron (Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: a randomized double-blind clinical trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339650/ Avicenna J Phytomed. 2018;8(6):513-523.

42. Blasco-Fontecilla H et al. Effectivity of saffron extract (Saffr'Activ) on treatment for children and adolescents with attention deficit/hyperactivity disorder (ADHD): a clinical effectivity study. https://pubmed.ncbi.nlm.nih.gov/36235697/ Nutrients. 2022;14(19):4046.

Copyright (C) Orthokennis https://www.orthokennis.nl/nutrienten/saffraan 


*A.A. Noorbala et al., Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial, geraadpleegd via de link: http://pubmed.ncbi.nlm.nih.gov/15707766/ 

*Shahin Akhondzadeh et al. Phytother Res.2005 Feb. Geraadpleegd via de link:https://pubmed.ncbi.nlm.nih.gov/15852492/ 

2. Dr. G. Verhelst, Groot handboek geneeskrachtige planten.